Hernia Mesh: General Surgeons Slow to Move on From Synthetic Mesh

P4HB mesh proves safe and effective in ventral hernia repairs, with low recurrence and complications, offering a safer alternative to synthetic mesh

SANTA BARBARA , CA, UNITED STATES, January 21, 2025 /EINPresswire.com/ -- “Our study demonstrates that the use of P4HB mesh is both safe and effective in ventral hernia repairs,” states Dr. Daniel H. Tran, General Surgery, Texas A&M College of Medicine.

Dr. Greg Vigna, national mid-urethral sling attorney and hernia mesh attorney, says, “The Phasix mesh is P4HB and is a natural polymer derived from E coli, fully degradable, and the safer alternative design for the defective synthetic mesh on the market. P4HB is completely removed by the body over twelve to eighteen months, so chronic complications are reduced to a minimum, while synthetic mesh causes chronic inflammation forever. There appears to be little justification for using polypropylene or other synthetic mesh at this time.”

What does Dr. Daniel Tran say in “The use of poly-4-hydroxybutyrate (P4HB, Phasix) mesh in ventral hernia repair: a systematic review and meta-analysis” published in Hernia (2024) 28:989-1004?:

“This study aims to investigate the efficacy and safety profile of poly-4-hydroxybutyrate (P4HB) mesh for ventral hernia repair through a systematic review and meta-analysis.

Sub-meta-analysis restricted to studies with follow-up> 18 months continues to show low rates of recurrence of 9%.

Our study demonstrates that the use of P4HB mesh is both safe and effective in ventral hernia repairs. When further analyzed past 18 months, the time when P4HB mesh fully resorbs, the rates of hernia recurrence, surgical site infection, and any complications
remain low upwards of 5 years and comparable to the rates seen in synthetic and biologics in similar patient populations.”

Read Dr. Tran’s article: https://link.springer.com/article/10.1007/s10029-024-02996-z

Dr. Vigna concludes, “The literature is closing the door on synthetic mesh, and unfortunately, general surgeons continue to select synthetic mesh and all of the complications that come with it. We are investigating complications of ventral hernia repair that include both early and late infections and other late complications. General surgeons who select polypropylene mesh are exposing their patients to unnecessary complications that are essentially eliminated with P4HB because the mesh is completely resorbed.”

Dr. Vigna is a California and Washington DC lawyer who focuses on serious injuries caused by defective devices including the Coloplast Altis sling and Bard Hernia Mesh. He represents the injured from defective hernia mesh and litigates these cases with the Ben Martin Law Group, a national pharmaceutical injury law firm in Dallas, Texas.

Click here for a FREE BOOK on Vaginal Mesh Pain: https://vignalawgroup.com/publications/

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Greg Vigna, MD, JD
Vigna Law Group
+1 8178099023
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