PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation
Most synapses in the central nervous system are in direct contact with perisynaptic astrocyte processes (PAPs)[1], forming the “tripartite synapse”[1]. At the tripartite synapse, astrocytes clear excess neurotransmitters, maintain ion homeostasis, and …